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Formulation And Evaluation Of Self-Microemulsifying Dispersible Tablets Of Ibuprofen
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| Author:
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DEVANJALI BHATTACHARJEE, AFRASIM MOIN, NIRMALA NAYAK, PREETHI S, MEENAKSHI S, SIDDARAMAIAH, NITHIN K S, D V GOWDA
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| Abstract:
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Aim: The aim of the present study was to formulate the self-micro emulsifying dispersible tablets of Ibuprofen (IB) and promote the dissolution and bioavailability of ibuprofen.
Methods: Badam Gum (BG) was added as a adsorbent into optimized liquid self-micro emulsifying drug delivery system (SMEDDS) of ibuprofen to prepare Solid self-micro emulsifying dispersible tablets dispersible tablets by wet granulation method.
Results: The composition of optimized liquid IB SMEDDS contains 17 % of Labrafil M was oil state, 28% of Cremophor EL as surfactant and 9.34% of PEG 400 as Co surfactant based on the result of Solubility test, self-emulsifying grading test, droplet size analysis, and ternary phase diagrams. Badam gum was added as a adsorbent into the optimized liquid IB-SMEDDS formulation to prepare the dispersible tablets by wet granulation compression method. The absorption capacity of silica (insoluble material) was higher (2.9g/g) than that of BG (0.9 g/g) (soluble material). Percent of IB released from silica within 45 min was less than 78%, while the percent of IB released from BG was 97.12%. In vitro reconstitution study con?rmed the IB SMEDDS dispersible tablets had good quality. SEM images exhibited that the prepared IB- SMEDDS dispersible tablet had no effect on the morphology of the emulsion droplet of the SMEDDS system.
Conclusion: In conclusion, this study would help to the application of the solid self-micro emulsifying technology to enhance solubility and dissolution of poorly water-soluble drug like Ibuprofen.
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| Keyword:
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Self-micro emulsifying dispersible tablets; Ibuprofen; Badam Gum; Absorption capacity; In vitro reconstitution study
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.525
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| Download:
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