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Evaluation of The Effect of Aqueous Extract of Lepidium Sativum Seed on The Adverse Effects of Rat Liver Injury Induced by Sodium Nitrite
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| Author:
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MAYTHAM ALI KAREEM, ASHWAQ KADHEM OBEID
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| Abstract:
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Objective: This study aims to reveal the biological vitality of cress seed (Lepidium sativum) aqueous Extract in protecting liver tissue from oxidative stress induced by toxicity Sodium nitrite(NaNO2).
Methods: 24 Male albino rats were Divided at random into four groups each group include 6 rats dosed for one month :The first group a control group Negative,The second group is dosed with NaNO2 in 30 mg /kg concentration orally by gavage ,The third group: normal rats is dosed aqueous extracts of Lepidium sativum seeds 550 mg /kg, The fourth group: is normal rats treated aqueous extracts of Lepidium sativum seeds 550 mg /kg and before 2 hour of taking NaNO2 with 30 mg/kg
Results: The aqueous extract Lepidium sativum seeds is dosed of 550 mg/kg orally protected the NaNO2 induced liver toxicity in albino rat by increase in the ALP and ALT, AST enzymes . Histologically the activity of extract was also protect the liver damage induced by (NaNO2) is represented by congestion central vein degeneration hepatic cell ,necrosis hepatic cell ,irregular arrangement of hepatocytes and increased infiltration of inflammatory cells.
Conclusion: The study suggested that the aqueous extract of Lepidium sativum seeds reinforces the oxidative stress defense status against hepatotoxicity .
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| Keyword:
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Lepidium sativum seeds, Histopathology. Liver, Sodium Nitrite.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.579
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| Download:
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