|
Acute Toxicity Test of Stichopus hermanii (Golden Sea Cucumber) in vivo for therapy in dentistry
|
|
| Author:
|
NOENGKI PRAMESWARI, BAMBANG SUCAHYO, LISDIANA TANDJUNG
|
| Abstract:
|
Acute toxicity test contribute to develope herbal material to be used as a drug. Stichopus hermanii contains bioactive compound and because of their small size less than 10 nm, their way easily to enter the human body may disrupt the cell normal biochemical environment. The use of Stichopus hermanii for therapy in dentistry is still unknown as it is safe and doesn’t cause side effect. The aim of this research was to prove that Stichopus hermanii solution for therapy in dentistry didn’t cause acute toxicity in a short term use. 18 Cavia cobaya male was divided into 3 groups. K(1) was negative group. K(2) was positive groups for 1 days by provision of Stichopus hermanii solution 3,5% with a dosage of 0,09ml/kg BB. K(3) was positive group for 1 days by provision of Stichopus hermanii 3,5% with a dosage of 0,36ml/kg BB. The results of biochemical blood serum that has been observed was SGPT, SGOT, BUN and kreatinin. With kit Biocon Diagnostic method quantitatively. Then analyzed the hipotesis test can be done by comparing with one way ANOVA test. Anova test showed that there is no significance difference between 3 groups in all parameters. Stichopus hermanii solution 3,5% didn’t cause increase levels SGOT, SGPT and decrease levels BUN, kreatinin. Stichopus hermanii solution for therapy in dentistry didn’t cause acute toxicity in a short term use.
|
| Keyword:
|
stichopus hermanii, acute toxicity test, therapy in dentistry
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2020.12.03.493
|
| Download:
|
Request For Article
|
|
|