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Formulation and in vitro evaluation of moxifloxacin hydrochloride ophthalmic inserts
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| Author:
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UPLOADED BY-ADMIN, PATEL U. L., CHOTAI N. P., NAGDA C. D., PATEL M. P., PATEL K.N.
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| Abstract:
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Moxifloxacin hydrochloride is a fluoroquinolone anti-infective agent useful in the
treatment of eye infection such as conjunctivitis, keratitis and keratoconjuctivitis. An attempt
has been made to formulate ophthalmic insert of moxifloxacin hydrochloride using
hydroxypropyl methylcellulose (4 -7%), methylcellulose (2-3.5%) and polyvinyl alcohol
(4 -7%) as polymers by solvent casting method with aim of increasing the contact time,
achieving controlled release, reduction in frequency of administration and greater therapeutic
efficacy. The prepared ophthalmic insert were then evaluated for uniformity of
thickness, weight, drug content, % moisture absorption, % moisture loss, folding endurance
and surface pH. In vitro drug release of formulated batches of ophthalmic insert was
performed by studying the diffusion through artificial membrane (prehydrated cellophane).
FTIR spectroscopy was performed to study the interaction of drug in formulation
using KBr disc method. On the basis of all physicochemical parameters and in vitro drug
release studies, the formulation (F12) with PVA (7%) was found to be promising and it
was selected as an optimized formulation. The result of in vitro diffusion study of promising
formulation (F12) exhibited first order kinetic, which is non-fickian in nature. The
Higuchi plot revealed that the release might be diffusion controlled.
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| Keyword:
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Moxifloxacin hydrochloride, ophthalmic inserts, HPMC, MC, PVA, in vitro
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| EOI:
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| DOI:
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