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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation and in vitro evaluation of moxifloxacin hydrochloride ophthalmic inserts

Author: UPLOADED BY-ADMIN, PATEL U. L., CHOTAI N. P., NAGDA C. D., PATEL M. P., PATEL K.N.
Abstract: Moxifloxacin hydrochloride is a fluoroquinolone anti-infective agent useful in the treatment of eye infection such as conjunctivitis, keratitis and keratoconjuctivitis. An attempt has been made to formulate ophthalmic insert of moxifloxacin hydrochloride using hydroxypropyl methylcellulose (4 -7%), methylcellulose (2-3.5%) and polyvinyl alcohol (4 -7%) as polymers by solvent casting method with aim of increasing the contact time, achieving controlled release, reduction in frequency of administration and greater therapeutic efficacy. The prepared ophthalmic insert were then evaluated for uniformity of thickness, weight, drug content, % moisture absorption, % moisture loss, folding endurance and surface pH. In vitro drug release of formulated batches of ophthalmic insert was performed by studying the diffusion through artificial membrane (prehydrated cellophane). FTIR spectroscopy was performed to study the interaction of drug in formulation using KBr disc method. On the basis of all physicochemical parameters and in vitro drug release studies, the formulation (F12) with PVA (7%) was found to be promising and it was selected as an optimized formulation. The result of in vitro diffusion study of promising formulation (F12) exhibited first order kinetic, which is non-fickian in nature. The Higuchi plot revealed that the release might be diffusion controlled.
Keyword: Moxifloxacin hydrochloride, ophthalmic inserts, HPMC, MC, PVA, in vitro
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