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In vitro Anti-inflammatory and In vivo Wound Healing Activity of Gardenia gummifera L.f Fruit Methanol and Stem bark Ethanol Extracts in Rats
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| Author:
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, NM VINAYKUMAR, RIAZ MAHMOOD, V KRISHNA, B RAVISHNAKARA, S AJITH
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| Abstract:
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Gardenia gummifera L.f is a medicinal plant that belongs to the Rubiaceae family. The plant is well known for its traditional practice. The current investigation was to evaluate the wound healing and anti-inflammatory capabilities of Gardenia gummifera fruit methanol extract (GFME) and Gardenia gummifera stem bark ethanol extract (GSEE). The acute dermal toxicity, wound healing activity of excision, and incision in rat models were evaluated. Wound contraction and epithelialization periods were measured by the excision model and tensile strength was evaluated from the incision model. Similarly, denaturation of protein, human red blood cell (HRBC) membrane stabilization, proteinase inhibitory action was evaluated for the inflammatory action. In vivo, acute dermal toxicity of extracts did not show any toxicity. GFME and GSEE treated wounds showed effective healing capability as proven by increased wound contraction and less epithelialization period and higher tensile strength. The anti-inflammatory studies revealed that GFME and GSEE had significant anti-inflammatory capacity. The outcome of this present study displayed remarkable wound healing and anti-inflammatory action.
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| Keyword:
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Gardenia gummifera, Wound healing, Tensile strength, Anti-inflammatory
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.482
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| Download:
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