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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Stability of Lantana camara Linn. leaf extract cream base on the level of Fe, Mg, Zn and quercetin equivalent of flavonoid

Author: , MAURITIUS LAMBERTUS EDY PARWANTO, DAVID TJAHYADI, HOSEA JAYA EDY, RADITYA WRATSANGKA, ASSANGGA GUYANSYAH
Abstract: Lantana camara Linn. live as a wild plant. These plants can be used as a natural medicine ingredient. The leaves of these plants can be extracted and used as a cream component. Effectiveness of L. camara Linn. leaf extract cream influenced by various factors, including levels of active substances. Content of the active substance in the L. camara Linn. leaf extract cream affected by temperature and storage time. The temperature and storage time will affect the content of the active substance so that it affects the effectiveness of L. camara Linn. leaf extract cream. Aims of this study to determine changes in levels of Fe, Mg, Zn and flavonoids in L. camara Linn. leaf extract cream. L. camara Linn. leaf extract cream were used in this study are 3%, 4% and 5%, while the storage time used was 0 and 180 days. Storage of L. camara Linn. leaf extract cream at 45 oC. L. camara Linn. leaf extract cream has a semi-solid form, has a distinctive smell like extracts and colored like the leaf extract of L. camara Linn. The cream base at storage day 0 (H0) and day 180 (H180) had a pH of 6, while the L. camara Linn. leaf extract cream 3%, 4% and 5% have a pH value of 5. Cream base and L. camara Linn. leaf extract cream 3%, 4% and 5% homogeneous and not clumping. There is a difference in the dispersibility between the cream base and the L. camara Linn. leaf extract cream 3%, 4% and 5%. There were changes in levels of Fe and Zn in the L. camara Linn. leaf extract cream 3%, 4% and 5% for 180 days of storage. Levels of Mg in L. camara Linn. leaf extract cream 3%, 4% and 5% remain unchanged for 180 days of storage. After storage for 180 days, the levels of quercetin equivalent of flavonoid were the most stable in the type of L. camara Linn. leaf extract cream 4%, while the less stable was L. camara Linn. leaf extract cream 3%, and the most unstable was L. camara Linn. leaf extract cream 5%.
Keyword: L. camara Linn. leaf extract cream, Fe, Mg, Zn, flavonoid, quercetin
DOI: https://doi.org/10.31838/ijpr/2021.13.01.441
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