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Kaplan-Meier Survival Curve Analysis: Pregabalin Therapy in Patients with Central Post-Stroke Neuropathic Pain
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| Author:
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BANGUNAWATI RAHAJENG, IWAN DWIPRAHASTO, ZULLIES IKAWATI, TRI MURTI ANDAYANI
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| Abstract:
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Stroke patients commonly experience central post-stroke neuropathic pain. This study aimed to analyze the rate of pain reduction in central post-stroke neuropathic pain with pregabalin therapy.
This study used the observational analytic method. Data collection was conducted prospectively on 36 patients with central post-stroke neuropathic pain at two hospitals in Yogyakarta in 2016. They received pregabalin 75 mg/day. Pain levels were measured using a visual analogue scale at the start of therapy, and at week 2, 4, 8, and 12 of treatment. A survival analysis was then performed to determine the rate of pain reduction (time vs. pain reduction >50%) using the Kaplan-Meier survival curve and the log-rank test.
The results show that there : Pregabalin can significantly reduce central post-stroke neuropathic pain in 69.7 % patients after 12 weeks of treatment, but were no significantly difference in the rate of pain reduction between men and women, between the age groups <55 years and >55 years, between the onset of pain <12 months and >12 months, ,between <2 episodes of disease and >2 episodes of disease, between <2 medications used and >2 medications used.
Conclusion: Pregabalin can significantly reduce central post-stroke neuropathic pain in 69.7% patients after 12 weeks of treatment. Pain reduction was not influenced by gender, age, pain onset, history of diseases or history of the medications.
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| Keyword:
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Kaplan-Meier, pregabalin, central post-stroke pain, neuropathic pain
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.374
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| Download:
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