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Corn Fiber Gum as a Potential Platform for the Preparation of Bioadhesive Floating Tablets of Domperidone
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| Author:
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BHUMIKA MANGLA, ANUREKHA JAIN, DEEPINDER SINGH MALIK
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| Abstract:
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The study is designed to formulate and evaluate buoyant mucoadhesive tablets of Domperidone with an aim to augment its gastric residence with enhanced efficacy. Several formulations were prepared employing varied formulatory ingredients in different proportions viz. gums (corn fiber gum; CFG, polyacrylamide grafted gum; AG and HPMC-E4M) and effervescent agents (sodium bi-carbonate, glycine and citric acid). The tablets prepared were later evaluated for their physico-chemical properties, drug content, buoyancy, swelling and erosion studies with analysis of bioadhesive strength, drugs release profile and compare with that of standard HPMC-E4M based tablet. FTIR and DSC studies indicated non-existence of interactions between drug and excipients used in the formulation. The buoyancy studies revealed formulation (F7) to exhibit floating lag time and total floating time of 0s and >8h, respectively, indicating its instant floating and prolonged gastric residence properties. Swelling index (0.987) and mucoadhesive (78.65±0.73N) studies further exhibited significant swelling and bioadhesive characteristic of AG based floating tablet. The drug release kinetics indicated the F7 to follow zero order release (0.988) following non Fickian diffusion mechanism. Thus AG could prove to be a promising bioadhesive vehicle for the successful delivery of Domperidone with enhanced gastric residence and sustained release within the stomach.
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| Keyword:
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Acrylamide grafted corn fiber gum; Domperidone; floating tablet; gastro-retention; mucoadhesion
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.364
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| Download:
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