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Anti-Inflammatory and Analgesic Activities of Oxadiazoles Combined with the Nucleus of Benzothiazole
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| Author:
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VISHAL KUMAR, SATISH KUMAR SHARMA, RIZWAN AHMAD
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| Abstract:
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The study aims to synthesise and assess the anti-inflammatory and analgesic potency of derivatives from 2, 3, 3-benzathiazole. The present study has synthesised a number of derivatives for phosphorus oxychloride condensation (Benzothiazolyl Carboxyhydrazides and Aryl derivatives) namely two (5-substitutes-1,3,4-oxadiazol 2-yl). Benzothiazol (vt1-vt9). Synthesized IR, 1H NMR and mass spectroscopy compound structures have been established. Checking of all synthesised materials was performed at 50 mg/kg and 10 mg/kg p.o. Anti-inflammatory and analgesic function for in-vivo. There were also positive anti-inflammatory and analgesic results of some drugs.
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| Keyword:
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1,3,4-oxadiazole derivatives, Synthesis, Aryl acids, Anti-inflammatory activity, Analgesic activity and Spectroscopy
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.390
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| Download:
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