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Safe Use of Ocular Nanosuspension
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| Author:
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, GNANASAMPATH MADHAN, GOWTHAMARAJAN KUPPUSWAMY
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| Abstract:
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Nanosuspensions are promising measure candidates which will be used for enhancing the dissolution of poorly water-soluble medication. Nanosuspensions contain submicron mixture dispersion of pharmaceutically active ingredient particles in an exceedingly liquid section stable by surfactants. Nanosuspension addresses many issues relating to typical suspensions such as low intrinsic solubility and saturation of lachrymal fluids, low eye bioavailability, and large particle size irritation. Also, high ophthalmic dose-generated osmolarity is avoided. The hydrophobic drugs' saturation and inherent solubility in lachrymal fluids are increased by nanosuspension because of their unique nature while maintaining unharness and extended life in a sinister bag. Results showed a higher level of anti-inflammatory activity than micro-suspension with nanosuspension. Poor water-soluble, low leaky medicine controls typically the absorption rate by the dissolution in the eye fluid. Thus the solubility and dissolution rate of the drug square and permeability measure key factors for its bioavailability. Many formulation techniques have enhanced the dissolution of poorly soluble substances over the years.
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| Keyword:
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Nanosuspension, Ocular barriers, Pharmacokinetics, Ocular Toxicology, Applications, NSAIDs
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.386
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| Download:
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Request For Article
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