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Immunological features of infectious mononucleosis Epstein-Barr virus etiology in children
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| Author:
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, NURIDDIN U. NARZULLAYEV, MEHKRINISO R. MIRZOYEVA, ZILOLA D. KELDIYOROVA
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| Abstract:
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A comparative study of cytokines in clinically similar groups of patients requiring differential diagnostic search revealed significant differences in the level of indicators. At the height of the disease, the serum of children with infectious Epstein-Barr mononucleosis of viral etiology is characterized by an increase in the content of proinflammatory cytokines IL-1a (1.7 times), IL-ß (1.6 times) and INF-? (4.3 times). In severe infectious mononucleosis, there was a twofold increase in the level of IL-1a and IL-ß, a 7-fold increase in the concentration of INF-?, an increase in the content of IL-1Ra (2.3 times) in the blood serum and the INF-?/IL-4 coefficient (1.6 times). Correlations were also found between the levels of IL-1a and IL-1Ra (0.49), IL-1a and IL-4 (0.45), IL-1a and INF - ?, (0.64), INF - ?, and IL-4 (0.47), INF - ?, and the number of atypical mononuclears (0.37). Acute bacterial tonsillitis is characterized by a twofold increase in levels of IL-1ß and INF - ?, and acute viral hepatitis "?" - much more significant increase in the concentration of IL-Vetta (18 times), increased INF - ?, (2.3 fold) and increased levels of IL-1Ra (1.3 times).
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| Keyword:
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infectious mononucleosis, bacterial tonsillitis, hepatitis B.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.418
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| Download:
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Request For Article
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