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Mathematical Three - Compartment Model Analysis of Cholesterol Transport in Human and its Cardiovascular Related Dysregulation
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| Author:
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RAMANAMOORTHY KANDULA, RUPALI S. JAIN, SANDHYA KANDULA, B. SURENDRANATH REDDY
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| Abstract:
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Background: Cholesterol is a crucial basic and utilitarian substance in the human body which is just marginally soluble in water and in this way doesn't effectively flow in the circulation system. Besides, to control the circulatory transporting system of cholesterol in lipoproteins, a measure of cholesterol present relies upon and is constrained by cholesterol dietary intake content, internally de novo synthesis, utilization, and elimination; anomalous as well as uneven cholesterol levels have been appeared to prompt serious results, e.g., cardiovascular infections.
Results: To estimate high risk for the threat of cardiovascular disease and events due to imbalance cholesterol homeostasis leading to cause atheromatous plaque accumulation in the cardiovascular system. We have designed and developed a customized three-compartment model where it describes the first compartment defined as total cholesterol concentration present in the liver, consequently the second compartment defined as total cholesterol concentration present in the circulatory blood (bloodstream), and lastly the third compartment defined as total lipid concentration in the cardiovascular system. As per our study belief was to estimate the amount, rate, and concentration of cholesterol in the third compartment for which we have done a detailed review of physiological model parameters systemic blood flow circulation from the liver to the heart. The varying C3 were estimated to be predictable i.e. lowers and raises blood cholesterol concentration levels in the third compartment for k32= 0.8 min-1 and k32= 1.2 min-1. Further on, C3 increases followed by intake of a dietary meal rich in cholesterol content for a time interval of up to 3 h. Other conditions to cause an extreme rise in levels of bad cholesterol i.e. LDL levels (by postulating the value of mtis as 0 mg/min) which can be opposed by hindering endogenous cholesterol synthesis thus held by sinking the values of k=500mg2/min. Brisk of cholesterol flow between compartment II and III has been concurrently adjusted to monitor C3 fluctuations by decreasing k23=0.1 mg/min or escalating k32= 1.3 mg/min.
Conclusion: Dyslipidemia is a significant reason for cardiovascular syndrome, which is the most profound cause of death over the globe. Mathematical modeling of cholesterol homeostasis representing in a three-compartment model can help in aid choice of ideal precautionary measures and therapeutic strategies for cardiovascular-related diseases.
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| Keyword:
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high blood cholesterol, LDL, HDL, mathematical modeling, cardiovascular system, cardiovascular disease.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.551
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| Download:
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