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Characterization and Formulation of Transdermal Drug Delivery System of Piroxicam
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| Author:
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ROHINI BHATTACHARYA, AFRASIM MOIN, NANHI NANDINI, MEENAKSHI S, SIDDARAMAIAH, SATHISH BABU P, NITHIN K.S, D V GOWDA
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| Abstract:
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The present study aimed to characterize water-insoluble non- steroidal anti-inflammatory drug [NSAID], Piroxicam [PXC], and formulate a transdermal patch. Characterization of the drug was done by Differential Scanning Calorimetry [DSC] and Fourier-Transform Infrared Spectroscopy [FTIR]. Powder X-ray Diffraction [PXRD] was carried out to confirm the identity of crystals. The solubility of Piroxicam was increased by preparing co-crystals of Piroxicam with succinic acid. The co-crystals were prepared by using Piroxicam and Succinic acid both by fast and slow evaporation methods of crystallization. Acetone of HPLC grade was used as a solvent for crystal formation. Rod and hexagonal-shaped crystals were observed under a microscope and later the identity was confirmed by Powder X-ray Diffraction. The supersaturated mixture was prepared for transdermal formulation and permeation was enhanced by co-former. Fourier-Transform Infrared Spectroscopy and Differential Scanning Calorimetry confirmed that there were no interactions between the drug and conformer. Due to the formation of co-crystals, water solubility was enhanced which was confirmed by in-vitro dissolution. An in-vitro skin study was carried out for the prepared transdermal formulation. To conclude, the co-crystal based formulation of Piroxicam and succinic acid provides better solubility than the individual drug and offers promising results for drug permeation through the transdermal delivery system.
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| Keyword:
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Co-crystals, Supersaturation, Transdermal drug delivery, Piroxicam, Crystallization, Succinic acid
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.404
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| Download:
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