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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Assessment of the Quality of Life and the Level of Depression in Patients with Chronic Kidney Disease on Programmed Hemodialysis

Author: , AKSANA M. KARDANGUSHEVA, LILIYA V. ELGAROVA, ZARINA A. SHUGUSHEVA, IRINA H. ALMOVA, SOFIAT KH.
Abstract: The aim of the study was to identify the features of the quality of life (QoL) and the severity of depression in patients with chronic kidney disease (CKD) C5 receiving programmed hemodialysis (PHD) therapy in the Kabardino-Balkarian Republic. Material and methods We examined 86 patients (60 men and 26 women) with CKD C5, receiving PHD treatment. The average age of the patients was 55.5 ± 13.9 years. The study protocol included an assessment of the level of depression according to the CES-D scale, the level of QoL according to the KDQOL-SF™ questionnaire, the comorbidity index (CCI) according to the M.E. Charlson anthropometry, tonometry, determination of general and biochemical blood tests, parathyroid hormone (PTH) levels. Results High and medium CCI were detected in 67.4% of patients with CKD C5 on programmed hemodialysis (PHD), arterial hypertension was detected in 39.5% of patients, low hemoglobin levels were detected in 27.9% of patients. The QoL of the patients examined by us was characterized by low scores in all domains with the most pronounced decrease in scores on the scales of physical functioning and the burden of kidney disease. Depression symptoms according to the CES-D questionnaire were detected in 88.4% of patients. Factors have been identified that have a negative impact on QoL: older age, male gender, lack of family, lack of work, secondary education, high blood pressure levels, high heart rate, dialysis experience less than 1 year and more than 5 years, high CCI, low hemoglobin levels, hematocrit, blood plasma albumin, disorders of phosphorus-calcium metabolism. CCI, diastolic blood pressure, heart rate, calcium-phosphorus product had the greatest influence on the onset of symptoms of depression. Conclusions The results obtained by us can be used in planning the therapeutic, psychological, social, psychopharmacological support of patients on renal replacement therapy. The introduction of the methods we used to assess QoL and the level of depression in the protocol for the management of patients with CKD C5 in dialysis centers will make it possible to monitor the individual indicators of QoL and depressive symptoms of patients to assess the effectiveness of treatment of patients on dialysis and make timely decisions on the correction of the individual treatment strategy.
Keyword: chronic kidney disease, quality of life, depression, programmed hemodialysis, comorbidity index, arterial hypertension, calcium and phosphorus metabolism.
DOI: https://doi.org/10.31838/ijpr/2021.13.01.381
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