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The Correlation between Serum Iron Level and Transferrin Saturation with Reticulocyte Hemoglobin Equivalent (RET-He) in Routine Hemodialysis
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| Author:
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MOHAMMAD RUDIANSYAH, RUDI SUPRIYADI, LEONARDO LUBIS, RIA BANDIARA, ABDUL HADI MARTAKUSUMAH, RULLY MARSIS AMIRULLAH ROESLI, DEDI RACHMADI
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| Abstract:
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Introduction: Iron deficiency often occurs in patients with chronic kidney disease (CKD) stage 5 undergoing routine hemodialysis (CKD-5D). Reticulocyte hemoglobin equivalent (RET-He) is a more stable substance and is not influenced by acute and chronic conditions. RET-He examination as a new and easy parameter is needed besides serum iron levels and transferrin saturation in patients with chronic kidney disease (CKD) patients undergoing routine hemodialysis (CKD-5D). This study aimed to determine the correlation between serum iron levels and transferrin saturation with RET-He in CKD-5D.
Methods: This was a cross-sectional study in the hemodialysis unit of Hasan Sadikin General Hospital Bandung, Indonesia. Blood sampling was performed using the Sysmex automatic hematology tool with 35 parameters. The statistical test used Pearson correlation and Unpaired T-test. The correlation was considered significant when p<0.05 with a 95% confidence interval.
Results: There were 181 patients with CKD-5D, 137 patients had complete data, and 97 patients who fulfilled inclusion and exclusion criteria taken randomly as study subjects. Average of age was 48+13 years, male 53 (54.6%), median of HD duration 36 (12-168) months, hemoglobin 9.1 (4.7–13.7) gr/dL, serum iron (SI) 54 (14–166) µg/dL, total iron-binding capacity (TIBC) 234 (137–429) µg/dL, Trasnferrin saturation (Tsat) 22.2 % (10.1–75.1) and RET-He 31.7 (19.3–37.5) pg/cell. Serum iron was correlated with RET-He (r=0.348; p<0.001) and Tsat was correlated too (r=0.454; p<0.001).
Conclusions: There was a significant correlation between SI and Tsat levels with RET-He in CKD-5D patients.
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| Keyword:
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CKD-5D, Anemia, Iron deficiency, Transferrin saturation, RET-He
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.318
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| Download:
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