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Role of Oxidative Stress in phathophysiology of Cardiovascular Diseases: A Comprehensive Review
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| Author:
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, NIRAJ KUMAR SINGH, YASH KUMAR SINGH
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| Abstract:
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Oxidative stress is the key role player in the pathophysiology of cardiovascular disease (CVD). Elevated production of superoxide anion, hydrogen, peroxide, reactive oxygen species inhibit the activity of nitric oxide (NO) that leads to the accumulation of hydrogen peroxide (H2O2) and peroxynitrites within the vascular smooth muscle cells that can modulates the endothelial function including expression of pro-in?ammatory mediators phenotype and endothelium-dependent relaxation. A vast source of superoxide production includes lipoxygenages, xanthine oxidases, NADPH dependent oxidases, mitochondrial dependent oxidases. The adverse effecst of oxidative stress are endothelial dysfunction and decreased NO level in the vascular cell. The present study has been designed to provide the overview on the effect of oxidative stress growth, endothelial dysfunction, apoptosis of vascular smooth muscle cells in the cardiovascular diseases like hypertension and vascular molding.
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| Keyword:
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Oxidative stress, Reactive oxygen species, Cardiovascular Disease, Antioxidant.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.145
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| Download:
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Request For Article
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