IJPR  articles are Indexed in SCOPUS (2010 - 2021)Click Here     *Five Years Citation in Google scholar (2016 - 2020) is. 1451*        Now IJPR is Q2 in SJR Ranking     Scopus Coverage of IJPR (2010-2021 Issue 1)            

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Role of Oxidative Stress in phathophysiology of Cardiovascular Diseases: A Comprehensive Review

Author: , NIRAJ KUMAR SINGH, YASH KUMAR SINGH
Abstract: Oxidative stress is the key role player in the pathophysiology of cardiovascular disease (CVD). Elevated production of superoxide anion, hydrogen, peroxide, reactive oxygen species inhibit the activity of nitric oxide (NO) that leads to the accumulation of hydrogen peroxide (H2O2) and peroxynitrites within the vascular smooth muscle cells that can modulates the endothelial function including expression of pro-in?ammatory mediators phenotype and endothelium-dependent relaxation. A vast source of superoxide production includes lipoxygenages, xanthine oxidases, NADPH dependent oxidases, mitochondrial dependent oxidases. The adverse effecst of oxidative stress are endothelial dysfunction and decreased NO level in the vascular cell. The present study has been designed to provide the overview on the effect of oxidative stress growth, endothelial dysfunction, apoptosis of vascular smooth muscle cells in the cardiovascular diseases like hypertension and vascular molding.
Keyword: Oxidative stress, Reactive oxygen species, Cardiovascular Disease, Antioxidant.
DOI: https://doi.org/10.31838/ijpr/2021.13.01.145
Download: Request For Article
 




ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free