|
Association between Vitamin B12 Serum Level and Staging of Colorectal Cancer in Semnan City
|
|
| Author:
|
FARAHNAZ GHAHREMANFARD, ELHAM ZIAEIFAR, SHAGHAYEGH KAMIAN, ALIREZA HEJRATI, ATOUSA NAJMALDIN
|
| Abstract:
|
Introduction: The prevalence of colorectal cancer is on the rise, with a high prevalence of vitamin B12 levels. Some studies have reported vitamin B12 deficiency as a risk factor for colorectal cancer. We aimed to determine the relationship between serum vitamin B12 levels and the stage of disease in colorectal cancer patients.
Materials and Methods: This cross-sectional study was performed on 43 colorectal cancer patients referring to the Oncology Clinic of Semnan in 2016-2018. Patients received blood tests for serum vitamin B12 levels measurement. Data on age, gender, stage of disease, tumor penetration depth, regional lymph node involvement, remote metastasis, and tumor location were extracted from medical records and pathologic reports. Finally, the relationship between serum vitamin B12 levels and these variables was investigated.
Results: The mean level of vitamin B12 among women was significantly higher than that of men (P = 0.015). On average, 62.5% of patients with the stages 2 and 3 as well as 41.8% of patients with the stage4 showed abnormal serum levels of vitamin B12 (deficiency and partial deficiency), while no significant difference was seen (P=0.613). Vitamin levels in patients with lymph node involvement were higher than those without lymph node involvement, but there was no significant difference between them (P = 0.236). Also, levels of vitamin B12 in patients with distant metastases were higher than those without such metastases, but there was insignificant difference between them (P= 0.290).
Conclusion: More extensive studies with a larger sample size are recommended to evaluate the relationship between serum vitamin B12 levels and the disease stage in predicting the prognosis of colorectal cancer patients with vitamin B12 deficiency.
|
| Keyword:
|
Serum Vitamin B12 Levels, Colorectal Cancer, Disease Stage
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2020.12.04.534
|
| Download:
|
Request For Article
|
|
|