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Chemometrics-Assisted UV Spectrophotometric Method for Simultaneous Determination of Paracetamol and Tramadol in Divided Powder Dosage Form
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| Author:
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DINA CHRISTIN AYUNING PUTRI, MICHAEL RAHARJA GANI, FLORENTINUS DIKA OCTA RISWANTO
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| Abstract:
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Paracetamol and tramadol were commonly prescribed in combination as an anti-inflammatory agent. In Indonesia, a combination of these two drugs was compounded as divided powder dosage form. It was important to ensure the content uniformity of each compound to implement the patient-oriented medication. UV spectrophotometric combined with chemometrics techniques were developed to quantitatively analyze the content of paracetamol and tramadol in divided powder dosage form. Two multivariate calibration method namely principal component regression (PCR) and partial least squares (PLS) were applied in this study. After considering several statistical parameters such as coefficient of determination (R2), root mean square error of calibration (RMSEC), root mean square error of cross-validation (RMSECV), and root mean square error of prediction (RMSEP), the PLS model was chosen to be employed for determining the content of paracetamol and tramadol. The linear model for determining content of paracetamol and tramadol were y = 0.9877x + 0.4663 (R2=0.9959) and y = 0.9685x + 0.3401 (R2=0.9875), respectively. The chemometrics model was applied in the content uniformity analysis of divided powder dosage form samples.
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| Keyword:
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chemometrics, compounding, paracetamol, tramadol, UV spectrophotometric
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.075
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| Download:
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