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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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New Concepts Of Antigenic Shift And Antigenic Drift In Influenza And Corona - A Review Of Literature

Author: V.M.KAYAL , DR. M.P BRUNDHA, DR.VINAY SIVASWAMY
Abstract: The study aims to review the recent concepts of Antigenic shift and drift in viral strains of Influenza and Corona. The strains of Influenza and Corona are constantly under mutation. These viral envelopes compose of surface antigens like haemagglutinin - HA , Neuraminidase NA- antigens respectively. Hence, any minor changes in the genes responsible for the HA and NA proteins is termed as an antigenic drift. However, if it involves a major rapid change then it is referred to as an antigenic shift. In response to such changes , the body’s immune system adapts accordingly and produces antibodies against the mutated antigen.A thorough literature search was attempted to consolidate recent concepts of antigenic shift and drift of Corona and Influenza using search engines like Pubmed, Google Scholar. The articles were screened and then were analysed for obtaining significant conclusions.The recent genetic analysis performed by Lancet et al reveals similarity in receptors (receptor binding protein) in SARS and those present in bats. Further, it is also predicted that recent genetic recombination of the earlier corona strains might have contributed to SARS - CoV -2. The propagation of antigenic shift and drift is reported to be similar to that of HINI Influenza strains in recent studies.
Keyword: Antigenic drift, Antigenic shift , Corona, COVID - 19, Genetic Recombination , Mutation
DOI: https://doi.org/10.31838/ijpr/2021.13.01.267
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