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Colony-stimulating factor 1 (rs2050462 ) and Cluster of differentiation 44 (rs13347) Polymorphism, Their Association With Risk of Kidney stone in Iraqi Populations.
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| Author:
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MANAL M.KADHIM, HENADI N. MOHAMED
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| Abstract:
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Background: Urolithiasis, is a global problem affecting almost all populations in the world and it is a multifactorial disease caused by environmental, hormonal, and genetic factors. Objective: the present study was conducted to investigate the association of CSF-1 and CD44 with the risk of kidney stone. Methods: A total of 45 patients with Kidney stones were included in the study who were admitted to the hospital from the period between March to August 2019, and other groups consist of 45 healthy individuals. A three ml of blood samples were collected for polymerase chain reaction amplification and detection of CSF-1 and CD44. Results: Overall, highly significant differences can be found in the distribution of the genotype and allele frequencies of CSF-1(rs2050462) between the nephrolithiasis patients and control subjects (P< 0.001). The effect of CD44 polymorphism on susceptibility to nephrolithiasis, were different in the frequency of allele and genotype (rs13347) between patients and healthy controls, with statistically highly-significant (p< 0.001). Conclusion: Polymorphisms in CSF-1 and CD44 affect the risk of nephrolithiasis.
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| Keyword:
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Nephrolithiasis, CSF-1, CD44
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.518
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| Download:
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