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The significant impact of +105 A>C promoter polymorphism in IL-18 cytokine in patients with a kidney stone in Iraqi Populations.
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| Author:
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MANAL M.KADHIM, HENADI N. MOHAMED
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| Abstract:
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Background: Urolithiasis, the third most prevalent urologic disease, is complex and multifactorial. It is when a solid piece of material occurs in the urinary tract. Objective: the present study was conducted to investigate the association of IL-18 with the risk of kidney stone. Methods: A total of 45 patients with Kidney stones were included in the study who were admitted to the hospital from the period between March to August 2019, and other groups consist of 45 healthy individuals. A three ml of blood samples were collected for polymerase chain reaction amplification and detection of IL-18. Results: Overall, highly significant differences can be found in the distribution of the genotype and allele frequencies of IL-18 +105A>C between the nephrolithiasis patients and control subjects (P< 0.001). Conclusion: Thus, it is evident from our study that IL-18+105A>C is implicated in renal stone disease, and that the rare, C related allele is connected with higher susceptibility to nephrolithiasis.
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| Keyword:
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Nephrolithiasis, Urolithiasis, Gene Polymorphisms, IL-18
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.413
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| Download:
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