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The Protective Effect of Boswellia Against Carbimazole Incuced Reanl And Hepatic Toxicity on Male Rats
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| Author:
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AMAL UMRAN MOSA, IMAN HUSSEIN NASER, BAN HOSHI KHALAF
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| Abstract:
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Boswellia is a plant proved to have therapeutic and protective effects against huge number of remedies. On
other hand, carbimazole is a medicine utilized in treating cases of hyperthyroidism. Long use of carbimazole
can give rise to renal and hepatic toxicity which can be prevented by using boswellia plant.
Aim of study: estimation of the protective effect of boswellia against hepatic and renal toxicity resulted from
carbimazole long used.
Method: 30 albino male rats were used in this study; these animals were divided into 5 groups. Control group
fed with distill water for 60 days, plant group who fed with 400mg/kg/day for 60 days, Carbimazole group
which fed with 2mg/kg/day for 60 days, carbimazole and plant group which fed with 2mg/kg/day and
400mg/kg/day for 2 months, the final group were treated with 2mg/1kg/day carbimazole then with
400mg/kg/day boswellia for one month. After experiment duration, the animals were scarified and the hepatic
enzymes and renal parameter where measured. Histopathological studied also performed for liver and kidney
tissues.
Result: biochemical studies show decrease in the hepatic enzymes and renal function tests parameters. this
mean it has protective effects against carbimazole toxicity. In the same time, Histopathological observations
find that less inflammation and deterioration in the tissues of boswellia treated animals compared with animals
fed with carbimazole only.
Conclusion: boswellia can reduce and protect the animal from the renal and hepatic toxicity resulting from
carbimazole long used
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| Keyword:
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biochemical studies; hepatic enzymes; toxicity
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.294
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| Download:
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