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Study of some immunological markers (IL-8 and TGF-ß1) and it’s relation with Pneumocystis jirovecii infections
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| Author:
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DHAY A.AZEEZ, ADNAN H. AUBAID, GHADA B ALOMASHI
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| Abstract:
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Background: Pneumocystis carinii pneumonia (PCP) may cause severe respiratory distress. This is believed to be partly caused by the accumulation of neutrophils in the lung. Interleukin-8 (IL-8) is potent neutrophil chemo-attractants and activators, and have been implicated in the host response to micro-organisms. The role of pro-inflammatory and anti-inflammatory cytokines in Pneumocystis jirovecii pneumonia (PcP) of non-AIDS immunocompromised patients remains unclear. Objectives: we measured the levels of pro-inflammatory cytokines including IL-8 and anti-inflammatory cytokines including transforming growth factor (TGF)- ß 1 in bronchoalveolar lavage fluid (BALF) and in 79 immunocompromised patients with PCP diagnosed by BAL and explored their clinical importance. Results: Twenty-one subjects without evidence of lung abnormality were included as control group. Compared with control group, PcP patients had significantly higher BALF levels of IL-8 and TGF- ß 1.
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| Keyword:
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interleukine-8 (IL-8), transforming growth factor (TGF)- ß 1 bronchoalveolar lavage fluid, Pneumocystis jirovecii pneumonia.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.510
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| Download:
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