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Formulation, optimization and in vitro evaluation of lovastatin drug loaded solid lipid nanoparticles
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| Author:
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GANNIMANI VEERABHADRA RAO, GADELA VENKATA RADHA, M.KRISHNAJI RAO, S.BRITO RAJ, K.BHASKAR REDDY
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| Abstract:
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The primary goal is to incorporate poor bioavailable Lovastatin (< 5 percent) into Solid Lipid Nanoparticle (SLN) to improve Lovastatin's biopharmaceutical properties. In order to prepare the SLN the microemulsification Technique has been used with the application of 23 factorial design. The formulated SLN is investigated for its particle size (PS) and shape, zeta potential (ZP), polydispersity index (PI), entrapment efficiency (EE) and percentage yield. Among 8 formulations, SLN7 shows minimum PS of about 180.9±30.2nm which augment the dissolution, surface area and permeability of Lovastatin. SLN7 shows maximum ZP of about -44.5±1.42mV showing strong stability with good surface charge potential and PI of about 0.454±0.12 shows the monodisperse distribution pattern. SLN7 shows high EE of about 98.42±2.64 percent, percentage yield of about 92.42±2.18 percent, maximum in vitro drug release of approximately 96.48±2.40 percent at 24 hours with controlled and predetermined drug release pattern. SLN7 drug release obeys zero order release kinetics, non-Fickian diffusion mechanism with r2 value > 0.96 and release exponent 'n' value drops between 0.5-0.8 for peppas kinetic model i.e., the drug diffusion mechanism is based on lipid relaxation. From the data it shows that microemulsification technique was concluded to be an optimal technique for preparation of Lovastatin SLN formulation.
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| Keyword:
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Lovastatin; Lipid nanoparticle; In vitro drug release; In vitro release kinetic studies
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.488
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| Download:
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