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Article Detail
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The Effects Of Eleutherine Palmifolia On Depression Behavior, Mda, Bdnf, Serotonin And Norepinefrin Levels In A Rat Model Of Depression
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| Author:
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SHERLY LIMANTARA, MASRUROH RAHAYU, NOORHAMDANI, MOCH. ISTIADJID EDDY SANTOSO
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| Abstract:
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Background: Major Depressive Disorder is the most prevalent psychiatric disorder. Serotonin and norepinephrine are two of the most influential neurotransmitters in the pathophysiology of depression, and decreased BDNF levels induce depressive behavior in mice. Oxidative stress also plays a role in the etiology of depression and is characterized by increased levels of MDA. Local herbs with antioxidant effects or which affect neuronal plasticity, such as Dayak onions, can be investigated as an additional antidepressant therapy.
Objective: To investigate the effect of Dayak onion extract on depressive behavior, MDA, BDNF, serotonin, and norepinephrine levels in rats.
Methods: This was an experimental laboratory study that used a true experimental design (randomized control group, pretest-posttest design). Thirty rats were divided into six groups: negative control group (K-), positive control (K+), treatment 1 (P1), treatment 2 (P2), treatment 3 (P3), and treatment 4 (P4). Unpredictable chronic mild stress was given for six weeks in the K+, P1, P2, P3, and P4 groups. Therapy was given for four weeks. Group P1 was given fluoxetine 1 mg/kg body weight, groups P2, P3, and P4 were given an extract of Dayak onions; the doses were 100, 200, and 400 mg/kg body weight, respectively. Rat depressive behavior was assessed by SPT, TST, and OFT tests before and after treatment. MDA, BDNF, serotonin, and norepinephrine levels in the rat brain were measured using ELISA. Data analysis used ANOVA or Kruskal Wallis analysis and SPSS statistical tests with a = 0.05.
Results: There were no statistically significant differences in serotonin and norepinephrine levels between the K-, K+, P1, P2, P3, and P4 groups. Significant improvements were found in the SPT, TST, OFT tests, and the levels of MDA and BDNF. Significant differences in SPT improvement were found in the K+ and P3 groups. Significant differences in OFT improvement were found in the K+ and P2 groups, K+ and P3, and K+ and P4.
Conclusion: Dayak onion extract (1) improved depressive behavior and increased the level of BDNF, (2) affected MDA levels but had no effect on serotonin and norepinephrine levels in a rat model of depression.
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| Keyword:
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Dayak onion, depression, oxidative stress, neuronal plasticity, MDA, BDNF, serotonin, norepinephrine
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.113
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| Download:
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