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Association of pon1 q192r gene and metabolic disorder in chronic pesticide exposures
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| Author:
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YUTTANA SUDJAROEN, AIRADA SRIDON, KOWIT SUWANNAHONG, WANIDA PONGSTAPORN
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| Abstract:
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Paraoxonase 1 (PON1) enzyme is involved in organophosphate metabolism and neurodegenerative disorders, which is biomarker for dyslipidaemia, insulin resistance, cardiovascular diseases and hypothyroidism. Aims of this study were to investigate PON1 Q192R (rs662) gene polymorphism; and to evaluate the association of genotype and metabolic biomarkers in chronic pesticide exposures. Information concerning of pesticide exposures from 50 rice farmers and 50 control respondents was collected by questionnaire interviewing. Blood sample (6 ml) was collected from each volunteer and separated to serum, NaF- and EDTA-plasma. Serum cholinesterase (SChE), liver function test (LFT), fasting blood glucose (FBG), HbA1c and lipid profile was assessed using automatic analysers; and PON1 Q192R genotyping was analysed by PCR-RFLP. All of rice farmers were chronic exposed and more than 50% of them was used pesticide over ten years. Average of SChE level of both groups were significantly different, however, there were within normal range. Genotypes were significantly different between rice farmers (high frequency of RR genotype) and control (p=0.02). Metabolic parameters including FBG, HbA1c, cholesterol, triglyceride, HDL-c and LDL-c in rice farmers and controls were different (p = 0.035, 0.045, 0.03, 0.021, 0.037 and 0.025, respectively). RR genotype was associated to metabolic disorders including insulin resistance and dyslipidaemia in chronic pesticide exposures. This genotypic variation was need to be consider on metabolic disorder treatment especially statins therapy.
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| Keyword:
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cholinesterase inhibitors, dyslipidaemia, insulin resistance, metabolic disorder, paraoxonase-1 (PON1), PON1 Q192R genotype
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.407
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| Download:
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