|
Prolongation of QTc interval associated with Drugs Used in Management of COVID 19
|
|
| Author:
|
MUZAKKIR AMIR, IRAWATY DJAHARUDDIN, HARUN ACHMAD, MIRZA SYAFARYUNI, L TRI
|
| Abstract:
|
The recent outbreak of the novel coronavirus officially known as Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) has progressed into a global pandemic. The United States Food and Drug Administration (FDA) issued an emergency use authorization (EUA) for several established antimicrobials and investigational ones. However, further observations on patients receiving these drugs showed severe drug-drug interaction leading to potentially life-threatening arrhythmias. Corrected QT interval prolongation has been known as a resulting side effect of individual microbial drugs or interactions between several concomitantly used drugs, with resulting life-threatening arrhythmias. Furthermore, arrhythmic complication of COVID-19 oftenly necessitates the use of antiarrhythmic drugs, further increasing the risk of potential severe drug-drug interactions. This review aims to present current data concerning QT-prolonging risk of several drug used in the management of COVID-19 and potential drug-drug interactions between them.
|
| Keyword:
|
QTc interval, Drugs used, Management Covid-19
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2020.12.04.504
|
| Download:
|
Request For Article
|
|
|