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The Effect of Tomato Extract Supplementation to Interleukin-17 Serum Level in Women with Melasma
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| Author:
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LIZA AFRILIANA, LISYANI BUDIPRADIGDA, KIS DJAMIATUN
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| Abstract:
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Background: Melasma, a skin-aging-manifestation, at the face can affect the woman-quality of life. An additional-modalities is required to improve effectiveness and decrease side-effects of hydroquinone-cream, a melasma-gold-standard-treatment. Lycopene-rich-tomato-extract is considered, because it protects UV-light-induced-erythema and reduces oxidative-stress-induced-tissue-damage. IL-17-expression of melasma is higher than normal-skin. Lycopene supplementation suppresses IL-17 in cardiovascular-disease. IL-17 is not only produced by Th17-cells, but also by Treg-cells in the recent-studies.
Purpose: To determine whether tomato-extract supplementation influenced the IL-17-serum-level which accompanied by the reduced-mMASI-score, the recovered-indicator of melasma.
Methods: A true-experimental-clinic with a double-blind, randomized pre and post-test control design was performed in this study done in a dermatology-policlinic of Diponegoro-National-Hospital. There were 62 women with melasma based on consecutive-sampling, were grouped equally into treatment and control-group. They were examined for mMASI-score and IL-17-serum-level before and after-treatment. Those group received melasma-standard-therapy (hydroquinone-4%-cream and sunblock in the night and morning). Additionally, the treatment-group consumed one tomato-extract-capsule/day/patient for 12-weeks while control received a placebo. The statistical analyses used were Wilcoxon and Mann-Whitney-U test.
Results: The pre-treatment-IL-17-serum level and mMASI score between two groups was no different. The-IL-17-level of treatment-group significantly increased from pre-treatment to post-treatment (median (minimal-maximal) ng/ml, 33.3 (6.4-323) to 61.1 (13.7-380.3); p = 0.033). The significantly increase was not observed in control-group (47.5 (12.2-254.4) to 61.4 (8.4-417.1). A significantly-decrease-mMASI-score was found in both groups at the end of study (p < 0.001), however the decrease-mMASI-score was more clearly in treatment than control-group (p < 0.001).
Conclusion: The tomato-extract-adjuvant-therapy relates to a significantly-increase-serum-IL-17-level from pre to post-treatment accompanied with more pronounced decrease-mMASI-score in women with melasma.
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| Keyword:
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Melasma, tomato-extract, IL-17, mMASI-score.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.502
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| Download:
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