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Design, Development And Characterization Of Promethazine Hcl Orodispersible Tablet
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| Author:
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SHAH DHIREN P, PATEL SARANGKUMAR M
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| Abstract:
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The main objective of the present research work was aimed to prepare Orodispersible tablets of Promethazine HCl using a natural superdisintegrant to obtain quick onset of action without water. Natural superdisintegrat gives additional benefits like chemically inert, nontoxic, less expensive, biodegradable and also nutritionally beneficial. Orodispersible tablets are advantageous over conventional dosage form especially in paediatric and geriatric patients who have difficulty in swallowing (dysphasia) and it needs no water which is beneficial during travelling. The pre-formulation studies carried out check interaction between drug, natural superdisintegrat and other ingredients. Orodispersible tablets were prepared by using direct compression method using natural and synthetic superdisintegrants in different concentrations. Banana powder, Kyron and Sodium starch glycolate were used as a superdisintegrant in formulation. Before formulation, blends of API and excipients were prepared and evaluated for various pre-compression parameters and prepared formulations were evaluated for their post compression parameters. The optimized formulation was subjected for stability studies. FT-IR and DSC studies showed no interaction between drug and superdisintegrant. It can be concluded that as concentration of superdisintegrant increases disintegration time, dispersion time, and wetting time decreases and concentration of mannitol increases with disintegration time, dispersion time and wetting time decreases.Orodispersible tablets of PromethazineHCl using natural superdisintegrant (Banana powder) were successfully prepared. Formulations prepared by using Banana powder showed better disintegration time as well as drug release profile.
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| Keyword:
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Orodispersible tablets, Promethazine HCL, Banana powder
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.495
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| Download:
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