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Inhibition of Osteoporosis by Endophytes – A Computational Approach
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| Author:
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DR.S.DAISYLIN ANBU SUJITHA, CHELLAM JAYNTHY
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| Abstract:
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Introduction: Bone degenerative disorder results in osteoporosis unless being taken care of in the initial stage. Also, osteoporosis is a silent disease that will be observed only when the fragile bones undergo a fracture or a hairline crack. Drugs given for treating the disease often have side effects. Hence, alternative measures are searched for. Medicinal plants are exploited for their therapeutic applications.
Objective: The present work analyzes the osteoporotic potential of the endophyte Alangiumsalvi folium using computational methods.
Methods: The interactions of the components of endophytes with the target protein are studied using Discovery Studio 2.0. Pharmacophore analysis is also done.
Results: The interaction of the two components kaempferol and quercetin with the target protein has been analyzed using computational methods. Also, kaempferol shows more stable interaction with the target protein.
Conclusion: The compound kaempferol is expected to have more potential as an anti-osteoporotic behavior than quercetin.
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| Keyword:
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osteoporosis, endophytes, secondary metabolites, docking, Pharmacophores, computational analysis.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.143
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| Download:
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