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Preparation, Characterization and In-Vitro Evaluation of Erlotinib Gellan Beads
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| Author:
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, SOUMIYA SUKUMAR, SANTHIAGU AROCKIASAMY, MANJUSHA CHEMMATTU MOOTHONA
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| Abstract:
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Gellan gum is a high molecular weight water-soluble polysaccharide produced by the bacterial strain Sphingomonas paucimobilis ATCC 31461. Gellan is non-toxic and biodegradable. It is a product of microbial fermentation. Gellan gum is a linear polymer composed of glucose, rhamnose, and glucuronic acid in a 2:1:1 ratio. Gellan gum has great potential to be applied in several industries such as food and pharmaceutical due to its functional properties. The erlotinib-loaded gellan beads were prepared by ionotropic gelation method using calcium ions as a cross-linking agent. Erlotinib loaded gellan beads were characterized by Scanning electron microscopy and Fourier transform infrared spectroscopy to determine the morphology and functional group of the bead respectively. The drug loading, entrapment efficiency, and in vitro drug release studies were also performed. The erlotinib loaded gellan beads were spherical. Increased gellan gum concentration caused an increase in entrapment efficiency. The entrapment efficiency was lower with increased CaCl2 concentration. In vitro drug release study showed that the percentage drug release was much higher in citrate buffer than in phosphate and carbonate bicarbonate buffer. Therefore results indicate that gellan gum could be considered as a successful carrier in the sustained release of erlotinib.
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| Keyword:
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Gellan gum, Erlotinib, Ionotropic gelation, Entrapment efficiency, In vitro drug release
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.139
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| Download:
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