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3D Printing in Pharmaceutics: Role of Fused Deposition Modelling (FDM) in Drug Delivery
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| Author:
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AHMED M.SHKARA, MOWAFAQ M.GHAREEB
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| Abstract:
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Three-dimensional (3D) printing includes various manufacturing techniques that are based on the depositing of materials layer by layer to create 3D structures according to the digitally designed structure required. Recently, the involvement of 3D printing in pharmaceutical dosage forms has gained wide attention since the Food and Drug Administration (FDA) approval of the first 3D printed tablet, Spritam®. Fused Deposition Modelling (FDM) is one of the most common 3D printing technology, based on the extrusion of filaments loaded with active pharmaceutical ingredients (API), formulating various dosage forms, having the ability to manufacture complex designs with the required dose, shape, and release kinetics. FDM 3D printing technology is considered a potential tool to formulate personalized medicine tailored to the individual needs, enhancing the digital health revolution, and enabling the feasibility of remote formulation of various drug delivery systems. This article reviews the main 3D printing techniques and focuses on FDM technology and its application in manufacturing various dosage forms, and also materials used in this technique and parameters affecting the formulation. The main challenges and limitations are also discussed.
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| Keyword:
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3D printing; drug delivery; personalized medicine; polymers; FDM.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.109
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| Download:
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