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Monocyte chemoattractant protein-1, interleukin-1 beta, and Neutrophil gelatinase associated Lipocalin are upregulated in patients with diabetic nephropathy
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| Author:
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HAIDER JABBAR AL HASSANI, WASEN SAMI HAMEED, ALI M.JANABI, NAJAH R.HADI
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| Abstract:
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Background: Diabetes Mellitus (DM) is the most prevalent metabolic non-communicable disease in the world and diabetic microvascualr and macro vascular complications cause significant morbidity and mortality. One of the most prevalent microvascualr complications of DM is diabetic nephropathy (DN). Currently, there is a greater focus on early detection of nephropathy to bring about in best patient outcomes. Chronic elevation of blood glucose level leads to the endothelial cells lining the blood vessels take more glucose than normal. Since they don't depend on insulin, then they form more surface glycoprotein than normal and cause the basement membrane to grow thicker and weaker. In diabetes, the resulting problems are grouped under macro vascular complications due to damage to the arteries and microvascualr complications due to damage to the small blood vessels, damage to the kidney which can lead to chronic renal failure, eventually requiring dialysis. Diabetes mellitus is the most cause of adult kidney failure worldwide in the developed world.
Aim of the study: The aim of present study is to evaluate serum levels of Interleukin-1B (IL-1B) and Monocyte chemoattractant protein-1 (MCP-1) and urinary levels of Neutrophil gelatinase-associated Lipocalin in patients with type 2 diabetes according to the stage of nephropathy.
Patients and methods: During the period from August 2018 to January 2019, a total of 300 subjects were recruited. Among them, 150 patients were suffering from T2DM that had been selected from those who attended the Center of Diabetes and Endocrinology in Al-Sadr Teaching Hospital in Najaf. These patients were classified into three groups according to their albumin/creatinine ratio (ACR), including 50patients with mild diabetic nephropathy, 50 patients with moderate diabetic nephropathy and 50 patients with severe diabetic nephropathy. 150 apparently healthy subjects matching the same age with diabetic subjects were selected as a control group.
Result: Significant elevation in MCP-1, IL-1ß and NGAL levels have been found in mild, moderate and severe diabetic groups when compared to the control individuals.
Conclusion: Biomarkers MCP-1, IL-1B and NGAL may be highly linked to the degree of proteinuria. These immunological parameters were significantly increased in diabetic nephropathy. Thus, there is a potential association between these mediators and incidence of diabetic nephropathy among Iraqi patients.
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| Keyword:
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diabetic nephropathy, interleukin-1B, monocyte chemoattractant protein-1, Neutrophil gelatinase
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.471
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| Download:
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