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Nano Sponges for The Enhancement of Topical Sustained Delivery of Terbinafine HCl
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| Author:
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VISHAL B RAWAL, PREETHI S, ANANYA K V, AMIT B PATIL, DV GOWDA
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| Abstract:
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Nano sponges (NS) were formulated using ß-cyclodextrin as polymer and DMC as cross-linker following the hot melt method. For optimizing NS, the Box-Behnken design was adopted. The drug was loaded into Nano sponge by stirring method. The hydrogel was formulated using Carbopol. To know the compatibility between drug and polymer FTIR, DSC, HNMR studies were conducted. NS formulations were characterized by Particle Size, Entrapment efficiency, SEM, XRD studies. NS loaded hydrogel was evaluated by pH, in-vitro release, and spreadability studies. All prepared NS loaded with Terbinafine hydrochloride were assessed for particle size, physical properties, surface morphology, the yield of production, and entrapment efficiency. The Nano sponge-loaded gel formulation was clear, viscous, homogeneous and white-colored. Nano sponges loaded in a plain Carbopol gel base were assessed for drug content, pH, ability to spread, in-vitro release, antifungal activity and stability. Hence it can be concluded that Terbinafine HCl loaded Nano sponges as the topical gel is suitable for the treatment of dermatophytosis.
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| Keyword:
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Nano sponges; Terbinafine HCl; Anti-fungal; Cyclodextrins; Dermatophytosis
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.092
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| Download:
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