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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Assessment of Erythropoietin Levels and Correlation with Cytokines in Patients with Chronic Heart Failure.

Author: , GADAEV A.G, TURAKULOVR.I, QURBONOV A.K, SABIROV M.A, SAYFULLAYEV M.B, GADAEVA N.A
Abstract: Aim of the study:To study interdependence between pro-inflammatory cytokines and erythropoietin in chronic heart failure (CHF) patients with anemia. Materials and methods: For the study 95 patients with CHF that developed as a result of ischemic heart disease were chosen. Patients were divided into three groups. The first group consisted of 30 CHF patients with iron deficiency anemia. The second group consisted of 35 CHF patients with anemia of chronic disease. The control group consisted of 30 CHF patients without anemia. In all patients serum levels of ferrokinesis, erythropoietin and levels of pro-inflammatory cytokines (IL-1, IL-6 and a-TNF) were measured. Results: the study showed that in CHF patients with anemia of chronic disease (the 2nd group) serum levels of erythropoietin was lower than other groups with 6,4±1,12 mIU/ml (?<0,05). Only in limited number of studies correlation between erythropoietin levels and pro-inflammatory cytokines was examined, and they had contradictory results[3, 4, 8]. Statistically significant correlation was found between pro-inflammatory cytokines and erythropoietin levels. In CHF patients with anemia of chronic disease (2ndgroup) there was weak negative correlation (r= -0.24 ?<0.05) between erythropoietin and IL-1, strong negative correlation (r= -0.52, ?<0.001) between IL-6 and erythropoietin, and average negative correlation (r= -0.37, ?<0.05) betweenTNF-aand erythropoietin. In CHF patients with iron deficiency anemia and without anemia weak positive correlation was found between erythropoietin and pro-inflammatory cytokines. Conclusion: The study found, that in patients with iron deficiency and anemia of chronic disease serum ferritin, transferrin, hepcidin and erythropoietin levels were different, and in the last group erythropoietin levels were reliably low (6.4±1.12 mIU/ml, ?<0.05) compared to other groups; There was a negative correlation between cytokines and erythropoietin levels in disease development.
Keyword: Chronic heart failure, anemia, pro-inflammatory cytokines, erythropoietin.
DOI: https://doi.org/10.31838/ijpr/2021.13.01.127
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