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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Clinical and Angiocalibrometric Changes of Retina Vessels in Patients with Idiopathic Retinovasculitis

Author: USENKO VALENTINA, UMETALIEVA MAANA, GENTSELMAN DMITRY
Abstract: Aim is to analyze the clinical and calibrometric changes in blood vessels in patients with idiopathic retinovasculitis. Material and research methods: 106 patients (212 eyes) were examined, including 86 patients (172 eyes) with retinal angiitis and 20 people (40 eyes) - the control group (CG). The average age of the patients was 22.0 ± 0.17. The following clinical forms of fundus pathology were revealed - angioretinopathy - 9.3%; neuroretinopathy - 74.4%; maculopathy - 26.2%; macular degeneration - 29.6%. Autofluorescence optical coherence tomography (OCT) of retinal vessels with calibrometry (Cirrus HD-OCT Carl Zeiss) was performed along with the generally accepted modern methods of studying refraction, visual field, fundus. Results: in angioretinopathy, there was no clear tendency towards the predominance of one or another change in caliber in the vascular arcades. While in neuroretinopathies there is a significant expansion of the arteries (up to 103.7 ± 0.05µm and 107.7 ± 0.05µm in 79% (50 patients, 100 eyes) and 64% (41 patients, 82 eyes) versus 80 ± 0.33 µm in CG (P <0.05). At the same time, varicose veins (BBB and HBV) were revealed up to 149 ± 0.59 µm in 65% (42 patients, 83 eyes) and 71.8% (46 patients, 92 eyes), versus 120 ± 0.45 µm in the CG ((P < 0.001). Dilatation in the arterio-venous system indicates an active process of aseptic inflammation in the vascular wall and microcirculation disorder. In maculopathy, expansion prevails both in the arterial and venous systems - in the VVA and NVA up to 110 ± 0.06 µm and 104 ± 0 .05µm at 100% (24 patients, 45 eyes) (P <0.01) and in 75% (20 patients, 34 eyes); in BBB and HBV - 142 ± 0.57 µm and 157 ± 0.58 µm in 50% (12 patients, 22 eyes) and in 75% (20 patients, 34 eyes), versus 80 ± 0.33 µm and 120 ± 0.45 µm in CG (P <0.01).With macular degeneration, there is a tendency for both arteries and veins to narrow. BBA and NVA narrowed to 70 ± 0.56 µm and 68.4 ± 0.47 µm in 33.3% (13 patients, 17 eyes) and in 27.7% (10 patients, 14 eyes), BBB and HBV - up to 97 ± 0.21µm and 86.7 ± 0.36µm in 44.4% (16 patients, 22 eyes) and 61.1% (23 patients, 31 eyes) versus 80 ± 0.33µm and 120 ± 0.45µm in CG (P <0.05, P <0.01). Conclusion: OCT of retinal vessels and calibrometry reflect the activity of the pathological process, as well as the nature and degree of microcirculatory disorders in idiopathic retinovasculitis.
Keyword: angiography, angiocalibrometry, retinovasculitis.
DOI: https://doi.org/10.31838/ijpr/2021.13.01.125
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