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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Simple New Colorimetric Method Development for the Estimation of Flupirtine Maleate in Bulk and in Pharmaceutical dosage Form

Author: P.V.DUSE, K.G.BAHETI
Abstract: A simple, sensitive, accurate new analytical method based on colorimetric determination was developed and validated for the estimation of Flupirtine maleate in pure and pharmaceutical dosage forms. Flupirtine reacts with Sodium nitrite (NaNO2) and Hydrochloric acid (HCl) to form a yellow-colored compound and colored complex which can be estimated by colorimetrically. The color of the solutions has measured the absorbance at ?max 411 nm. Beers law was followed in the range of 10-50µg/ml respectively. The correlation coefficient was found to be 0.9998. LOD and LOQ were determined and found to be 0.103 µg/ml and 0.318 µg/ml respectively. The recovery studies were performed. The percent recovery was found to be 99.4 ± 1. The method was conducted and validated as per ICH guidelines. The proposed method was found to be precise, accurate and successfully validated for the routine analysis of Flupirtine maleate in bulk drug and in the formulation.
Keyword: Flupirtine, Sodium nitrite, Hydrochloric acid, Visible spectrum
DOI: https://doi.org/10.31838/ijpr/202 1.13.01.120
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0.12
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