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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation and Evaluation of Fast Disintegrating Tablet of Paclitaxel by Hydrotropy Technique

Author: , SYEDA SHABANA SULTANA, DR.K.APPANNA CHOWDARY, DR.SUMER SINGH
Abstract: The intention of this delve into study was to prepare and evaluate fast disintegrating tablet of Paclitaxel by hydrotropic solid dispersion techniques. The pharmacological retort of drug mainly depends on its absorption rate, which simultaneously depends on drug’s solubility which is a major parameter. Paclitaxel is anticancer agent useful in to treat the cancer, has poor aqueous solubility. The poor water solubility of medicament results in decreased bioavailability and insufficient therapeutic effect. In the present investigation, an attempt was made to improve the solubility and dissolution rate of a poorly soluble drug Paclitaxel by lipid-solid dispersions, liquisolid compacts, hydrotropy method and loaded solid dispersion methods and in the precompression studies solid dispersions by hydrotropy method was shown best fit for tablet formulation was selected for final tablet formulation. To increase the disintegration of the tablet formulation some super disintegrants are used such as sodium starch glycolate and crospovidone. Preparation of tablet by direct compression and evaluation were done. This study revealed the influence of hydrotropic agents in the improvement of solubility of Paclitaxel. Compatibility between drug and excipient examined by FTIR and DSC study.
Keyword: Hydrotropy, Paclitaxel, solubility, super disintegrants
DOI: https://doi.org/10.31838/ijpr/202 1.13.01.082
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