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Biochemical Biomarker Disorder Potential to Identify COVID-19 Patients in Iraq
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| Author:
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ALI A.H.ALBAKAA, THAER ALI HUSSEIN, WESSAM R.N.MOHSEN
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| Abstract:
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Background: A common effect of disease is disruption to serum electrolyte levels. Diseases responsible for this manifestation can be non-communicable or infectious. All aspects of patient care have been impacted by the (COVID-19) disease, occur due to infection with virus of SARS-CoV-2. Early studies of hospitalised COVID-19 patients report a putative relationship between the severity of infection and serum electrolytes, indicating these are potential diagnostic biomarkers of COVID-19 infection. Monitoring serum electrolytes as biomarkers of disease can assist with early diagnosis of COVID-19, as low or elevated concentrations of serum various electrolytes are associated with various inflammatory diseases. This study explores the effectiveness of using serum electrolytes as biomarkers for COVID-19 detection and clinically management of COVID-19 infected patients. Evaluation of efficacy of the method is determined by using a control group for comparison. The results reveal significant differences in the blood biochemical parameters among both study categories. The blood biochemistry picture of COVID-19 infected individuals is summarised.
Methods: A total of 100 fully confirmed COVID-19 infected subjects that attending to specialist laboratory during the period from August 2020 to September-2020 were included in this study and evaluated for their serum level of biochemical biomarker (Mg, P, Ca, Na, Cl, K).
Results: Of all the Covid-19 patients evaluated, we found that chloride (Cl) and magnesium (Mg) were respectively elevated in 20% and 15% of patients. Five per cent of patients had abnormal levels of phosphorus (P) and 73% of patients had reduced serum calcium (Ca), though it was increased in 1% of patients. Serum levels of potassium (K) were elevated in 37%, while 19% of patients had abnormal levels of sodium (Na).
Conclusions: The range of serum electrolyte abnormalities exhibited by some COVID-19 patients might indicate varying degrees of organ dysfunction. The severity of the disease may be reflected to an extent in abnormal biochemical readings of (Ca) and (Na), for example. The results of this study indicate that serum concentrations of electrolytes have clinical implications for the management of COVID-19 patient; therefore, to help provide the most appropriate care for these patients, blood tests should be performed to evaluate these biomarkers.
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| Keyword:
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Biochemical Biomarker Characteristics, Diagnostic Utility, Coronavirus Disorder 2019.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.476
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| Download:
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