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Article Detail
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Research Of Biotechnological Properties Of Microorganisms-Antagonists
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| Author:
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IRINA S.MILENTYEVA, LYUDMILA K.ASYAKINA, LYUBOV S. DYSHLYUK, NATALIA S. VELICHKOVICH, LEV A. OSTROUMOV
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| Abstract:
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Introduction.Today, there is a wide range of microorganisms that are resistant to existing traditional
antibiotics. Therefore, the development of new drugs with antimicrobial activity is an urgent direction.
In this paper, a study was conducted to study the antimicrobial, antibiotic, and biocompatible
properties of antibiotics produced by antagonistic microorganisms.
Materials and methods: In this article, antagonist bacteria isolated from natural sources of the Kemerovo
region- Kuzbass are studied. Antimicrobial properties, antibiotic resistance, and biocompatibility of bacterial
strains cultured on dense and liquid nutrient media were studied for these microorganisms. For each selected
strain of microorganisms-antagonists, antibiotic resistance to the action of one or more antibacterial drugs
was established, which reduce the sensitivity of the culture of microorganisms to the action of an antibacterial
substance.
Results of the study: when determining antimicrobial activity, it was found that out of 19 tested microorganisms,
only 11 (rod-shaped bacteria Geobacillus stearothermophilus, genus Bacillus, namely B. subtilis and B.
caldotena, genus Lactobacillus, namely L. plantarum, L. casei, and L. fermentum, spherical bacteria of the
genus Leuconostoc, namely L. lactis and L. mesenteroides, genus Pediococcus, and P. acidilactici, P.
pentosaceus, and P. damnosus that exhibit high antimicrobial activity against all test strains of pathogenic and
potentially pathogenic microorganisms.
Discussion and conclusions: The creation of complex antibacterial drugs that will consist of several
different types of microbial strains is a popular direction due to the development of new technologies.
That is why the biocompatibility of strains was evaluated to create combined drugs that are based on
research results. Positive biocompatibility was shown by strains of microorganisms of the genus Bacillus
(B. subtilis and B. caldotenax) and Leuconostoc lactis, and strains of the genus Lactobacillus (L.
plantarum, L. fermentum and L. casei), Leuconostoc mesenteroides, of the genus Pediococcus (P.
acidilactici, P. pentosaceus, and P. damnosus).
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| Keyword:
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antagonistic microorganisms, antimicrobial activity, antibiotic resistance, lactic acid bacteria.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.457
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| Download:
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