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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect Of Farnesol On Oral Pathogens- A Systematic Review

Author: SRUJANA HEMMANUR, IFFAT NASIM
Abstract: The presence of oral biofilms have been confirmed by various researchers and also their contribution in causing the commonly occurring oral diseases cannot be overlooked. The biofilms due to their properties are extremely difficult to be managed in clinical scenarios. One of the most common hurdles is the development of antimicrobial resistance. Hence, new antimicrobial agents must be tried and tested such that they are biocompatible and are bactericidal or bacteriostatic. Farnesol is a sesquiterpene alcohol commonly found in propolis and essential oils of citrus fruits that has been reported to have antimicrobial and antibiofilm properties. The aim of the study was to evaluate the antimicrobial properties of Farnesol and to determine its effect on the oral biofilms . A search was performed in the electronic database (i.e, PUBMED CENTRAL and Medline) using search terms alone and in combination by means of PUBMED search builder upto September 2019. Studies were selected if they met the following criteria: In vitro/ in vivo studies evaluating the reduction of antimicrobial load and biofilm biomass upon using Farnesol. The primary outcome measure was to evaluate the reduction of the microbial load and biofilm biomass. The results showed that there was a significant difference in the reduction of the antimicrobial load when Farnesol was used either alone or in combination with other antimicrobial agents.Based on this review, it may be concluded that Farnesol can be used to manage the oral diseases caused as a result of the oral biofilms.
Keyword: Farnesol,biofilm,oral
DOI: https://doi.org/10.31838/ijpr/2020.12.04.449
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