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Abnormalities in Neuromuscular Transmission - A Review
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| Author:
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GOWRI SETHU, VIGNESH RAVINDRAN
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| Abstract:
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The neuromuscular junction is the site of a number of different autoimmune and genetic disorders, and it is also the target of many neurotoxins from venomous snakes, spiders, scorpions and other species. Four of the ion channels or receptors are directly involved in autoimmune diseases. Neuromuscular junction disorders result from destruction, malfunction or absence of one or more key proteins involved in neuromuscular transmission. The most common pathology is antibody mediated damage or down regulation of ion channels or receptors, resulting in myasthenia gravis (MG), Lambert-Eaton myasthenic syndrome (LEMS), and acquired neuromyotonia (Isaac’s syndrome). The objective of the review is to assess the abnormalities of neuromuscular transmission. This brief review will concentrate on these conditions and also helps to understand the etiology of rare but treatable neurological syndromes of the central nervous system.
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| Keyword:
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Neuromuscular transmission, Abnormalities, Autoimmune, Neurotoxins, Myasthenia gravis, Lambert-Eaton Myasthenic Syndrome.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.378
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| Download:
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Request For Article
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