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Sirtuin Effect on Ageing- A Review
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| Author:
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NISHANTHI.R , M.P.BRUNDHA, VIGNESH RAVINDRAN
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| Abstract:
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Sirtuin is a class of protein that has many effects on disease such as gout , diabetes ,Alzheimer's disease the objective of this review is that sirtuins has the effect of extending the age. Sirtuins are regulated by the cofactor NAD and thus may serve as sensors of the metabolic state of the cell and organism. Extensive searching was done in PubMed, Scopus index and many other databases. In this review we examine the roles of Sirtuins in diverse eukaryotic species, with special emphasis on their links to ageing. The study of ageing in invertebrate model organisms has produced fundamental new observations about mechanisms of eukaryotic ageing. Among the genes that have been shown to regulate ageing in different species are SIR2 and its functional orthologs that make up a family of protein deacetylases termed sirtuins.
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| Keyword:
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Sirtuins, cellular ageing, protein deacetylases
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.374
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| Download:
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