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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evaluation of mean platelet volume before and after iron deficiency anemia treatment.

Author: SAFA A.FARAJ, ALAA M. AL-RUBAE, AHMED I. ANSAF
Abstract: Iron deficiency anemia (IDA) is the most common nutritional anemia and a significant public health problem in the world. Iron reduces megakaryopoiesis so that anemia with iron deficiency (IDA) contributes to micro thrombosis. Iron treatment improve thrombocytosis. Aims: the purpose is to assess the importance of mean platelet volume (MPV) in the diagnosis of iron deficiency anemia (IDA) in low-setting regions. Patients and methods: From the period January 1st, 2016 to December 31st, 2018, in the pediatric unit of the AL-Karama teaching hospital, a retrospective study was carried out. A total of 51 patients diagnosed with iron deficiency anemia (35 were males, and 16 were female). The mean patients’ age was 4.9 years, ranging from 9 months to 14 years. Patients with other types of anemia were excluded. Result: In the pretreatment phase, the mean Hb was 8.1 g/dl, mean MCV was 60.7FL, and the MPV was 5.8FL. In the post-treatment phase, the mean Hb was 10.7g/dl, mean MCV was 68.2 FL, and the MPV was 6.7 FL, p-value (0.0001) was significantly higher in post-treatment group than those in pretreatment group and all patients respond to treatment. From the ROC curve analysis of MPV in patients in pretreatment and post-treatment period, the sensitivity was 76% and specificity 47% at a cut-off level of 5.8. Conclusion: MPV can be considered as marker that help in diagnosing iron deficiency anemia and for follow up.
Keyword: Iron deficiency, platelet volume, blood parameter.
DOI: https://doi.org/10.31838/ijpr/2021.13.01.081
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