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Biochip test systems in differential diagnosis of metastatic lymph nodes.
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| Author:
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SEIDALIN N.K., BENBERIN V. V., SHANAZAROV N. A., TULEUBAEVA A. A., SATAEVA ?.S, TOKHPANOVA N. A., ISABEKOVA A. M.
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| Abstract:
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Data were obtained from a comparative study of various types of biomaterials, sensitivity and specificity of the method of immunocytochemical biochip testing for various pathological conditions of lymphoid tissue (inflammatory or infectious processes, metastatic lesions and lymph-proliferative diseases) in comparison with the standard (cytological or histological or immunohistochemical study, depending on the pathology).
Results: The results of the study showed that biochip test systems for carrying out immunological analysis of cytological material in conditions of preserved cell morphology allow specific detection of membrane and intracellular structures (antigens) using labeled antibodies (fluorescently) and they are a component for differential diagnostics between inflammatory, metastatic and lymph-proliferative diseases.
Conclusion: In the field of primary diagnostics at the level of primary care organizations, fluorescent immunocytochemical methods using biochip test systems make it possible to make a differential diagnosis between inflammatory diseases of the lymph nodes (lymphadenopathy), metastatic lymph node damage and lymph node damage in lymphomas with high sensitivity and specificity in the period from 30 to 60 minutes using minimally invasive techniques.
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| Keyword:
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lymphoma, Hodgkin's lymphoma, lymph node metastases, non-Hodgkin's lymphoma, immunocytochemistry, immunohistochemistry, biochip.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.420
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| Download:
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