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Association of human papillomavirus (HPV) with Urothelial Carcinoma in the south of Iraqi patients.
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| Author:
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AWS RASSUL HUSSAIN AL-SALIH
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| Abstract:
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Background: Forty types of human papillomavirus can be transmitted through sexual contact, most of these types are capable of infecting and incorporating viral DNA into the epithelial lining of urogenital organs triggering tumorigenic development. UC is considered one of the most common malignancies in the world that affect both men and women, yet the relationship between HPV infection and developing urothelial carcinoma is still not fully understood. Objectives: This study investigated the association between high-risk HPV (HPV-16 and HPV-18) infection and the development of urothelial carcinoma in Iraqi patients. Results showed a positive correlation between being positive with HPV and the development of a higher stage and grade of bladder cancer. Patients with advanced age were presented with significantly higher HPV prevalence and subsequent advanced muscle-invasive type of the carcinoma. Conclusion: Further studies are still needed to understand the molecular mechanism that governs the development of bladder carcinoma in HPV- positive patients and the role of HPV vaccination in controlling the spreading of the disease globally.
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| Keyword:
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human papillomavirus (HPV); Urothelial Carcinoma; Transitional Cell Carcinomas (TCC); sexual contact.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.369
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| Download:
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