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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Review on Understanding Drug dosage Regimens and its Design- The First-step Towards Rational Prescribing

Author: PRASAATH SASTHA.K.R, RAMALINGAM KOTHAI, KATHIRVEL. R, BALASUBRAMANIAN ARUL
Abstract: The primary goal of any drug therapy is to produce intended therapeutic effects without or with minimal adverse or toxic outcomes. Every prescriber or clinician intends to provide a therapy that meets this goal. It is crucial to recognize the significance of pharmacokinetics of the drugs in any drug therapy to attain the goals of the therapy. Moreover, each patient responds to drug therapy based on their existing pathological and physiological conditions. Every prescriber needs to understand that the drugs must be administered at the right dose during the right time for the right duration to manage the patient efficiently. While prescribing drugs with a narrow therapeutic index, the main goal of designing a dosage regimen is to make the drug therapy optimized for the patient’s pharmacokinetic profile so that the administered dose of the drug produces the intended therapeutic action and not other toxic effects. This review mainly discusses the significance of designing a dosage regimen and calculation of doses for varying situations and routes of administration for a patient by considering the individual’s pharmacokinetic profile. Dosing special populations like children and elderly patients needs to be individualized because of their varying pharmacokinetics to improve the therapeutic outcomes. Patients with renal and hepatic diseases must be treated with proper doses of drugs as the organs affected are pivotal in drug metabolism are elimination. Calculation of doses for the patients must be done with precision by the clinicians as it is their duty to provide such high quality of care to the patients.
Keyword: Pharmacokinetics, Dosing design, Paediatric, Geriatric, Hepatic impairment, renal impairment.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.419
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