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Design And Evaluation Of Medicated Dermal Patches Of Proton Pump Inhibitor-Esomeprazole
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| Author:
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M.R.SHIVALINGAM , ARUL BALASUBRAMANIAN, KOTHAI RAMALINGAM
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| Abstract:
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Transdermal Drug Delivery System (TDDS), an innovative technique; releases the drug via the skin into systemic circulation at a predetermined manner at a controlled rate to sustain the release and to improve the safety and therapeutic efficacy of the drug for better patient compliance. An attempt was made in the present study to formulate an alternative dosage form as transdermal patches for Proton pump inhibitor (PPI) Esomeprazole which exists as a conventional and parenteral formulation for peptic ulcer treatment. To indicate that the drug is compatible with the formulation components, Drug-Excipient compatibility studies were performed using FT-IR. Transdermal patches of Esomeprazolewere prepared by the solvent evaporation method in which HPMC with PVP and HPMC with Eudragit L100 polymers were used in different ratios. All the formulated patches were evaluated for various parameters such as thickness, folding endurance, percentage moisture content, weight uniformity, swelling index, percentage moisture content, moisture uptake, water vapour transmission rate, and surface pH. All the formulated patches in this study satisfy characteristics related to integrity, flexibility, dispersion of drugs, and other quality control parameters. In vitro release studies of transdermal patches of ESMshows maximum availability of the drug in the systemic circulation (93.14 and 92.12 %), which in turn shows maximum bioavailability.
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| Keyword:
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Peptic ulcer; Transdermal Patch; Solvent evaporation method; Prolonged Release.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.418
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| Download:
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