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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Efficcacy of Tagetes erecta Linn. leaf extract cream on rat dermal wound healing

Author: , MAURITIUS LAMBERTUS EDY PARWANTO, DAVID TJAHYADI, HOSEA JAYA EDY
Abstract: Dermal wound of the human body are a problem that must be cured immediately. Therefore it is necessary to look for new herbal medicine options. The purpose of this study was to determine the effectiveness of the dose of Tagetes erecta Linn. leaf extract cream on rat dermal wound healing. This study is an animal treatment in Wistar rats. Rats were divided into 3 groups, namely groups I, II and III. All rats in the treatment groups were excision on the back skin. Group I (control) after excision was given the drug nitrofurazone cream, group II was given T. erecta Linn. leaf extract cream 3% and group III was given T. erecta Linn. leaf extract cream 4%. T. erecta Linn. leaf extract cream 3% and 4% play a role in increasing the strength of wound contraction, the percentage of wound contraction and accelerating the epithelialization period compared with the positive control group (nitrofurazone). T. erecta Linn. leaf extract cream 3% and 4% better as antibacterial than positive control (nitrofurazone). T. erecta Linn. leaf extract cream 3% and 4% increase protein and DNA content in the wound area compared with the positive control group (nitrofurazone). T. erecta Linn. leaf extract cream 3% and 4% can be followed by clinical trials in humans so that it can be an option for treating on dermal wounds healing.
Keyword: Tagetes erecta Linn. leaf extract cream, wound healing, epithelialization period.
DOI: https://doi.org/10.31838/ijpr/2021.13.01.020
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