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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Antioxidant Activity and Acute Toxicity of New N4 -Substituted5-(1,2,4-Triazole-1-Ylmethyl)-1,2,4- Triazole-3-Thiones And S - Derivatives

Author: S.S.ZYKOVA , G.V.TSAPLIN, V.S.TALISMANOV, I.P.BULATOV, S.V.POPKOV, ?.G.KARMA
Abstract: In the present study N4 -substituted 5-(1,2,4-triazole-1-ylmethyl)-1,2,4- triazole-3-thiones and S - derivatives were screened for antioxidant activity in vitro by DPPH method and acute toxicity in vivo by OECD. The tested compounds 2,5 showed average antioxidant activity. The 1,2,4-triazol-3-thiones and S-derivatives mostly belong to 3 and 4 classes of toxicity by OECD.
Keyword: antiradical activity, antioxidant activity, radical scavenging effect, resveratrol, 1,2,4 -triazol-3-thione, Trolox
DOI: https://doi.org/10.31838/ijpr/2021.13.01.056
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0.12
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